2. Optimizing Vitamin D Levels and Improvement in Glycaemic Control:

An Observational Study from India

This original research was presented by Dr.Jothydev Kesavadev and team at the 25th Annual Meeting of American Association of Clinical Endocrinologists(AACE) in May at Orlando, Florida, USA.

There is a dearth of long term follow-up data from India on vitamin D status in diabetes patients and effect of vitamin D status on glycemic control.We followed up 2134 diabetes patients presenting at our centers for an year (34% female; age in years M:53.1, SD: 11.8). Vitamin D status was similar amongst male & female patients, with overall 60% deficient (<20ng/ml), 27% low(21-30ng/ml) and 12% normal (30-80 ng/ml). Patients were given comprehensive treatment for diabetes, dyslipidemia, hypertension, vitamin D deficiency, etc. as applicable, with telemedicine-based diabetes care. 599 patients visited the clinic again within a year.

At the second visit, only 23% were vitamin D deficient and 45% had normal values. Average HbA1c was 7.7+/-1.8 at first visit and 7.1+/- 1.5 at second visit. A multilinear regression with HbA1c as outcome and age, sex, insulin use, BMI, and vitamin D status (deficient, low, normal) as predictors showed statistically significant effect of final vitamin D status on final HbA1c level (β=-0.12, se=0.06,p=0.04). Vitamin D status may be optimised for better glycemic control and further well-designed studies are needed to elucidate the level of effect.


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