Recent research published in ‘Cardiovascular Diabetology’ reported a bidirectional association of C-peptide with CV markers in people without diabetes and in newly diagnosed diabetes.

The retrospective cohort study included a total of 55636 participants who had a health examination from 2017 to 2021. Cardiovascular biomarkers like high-sensitivity C-reactive protein (hs-CRP) and high-sensitivity cardiac troponin T (hs-cTnT) were measured and their relationships with fasting C-peptide were evaluated for all participants. Cardiovascular events were obtained during the last visit and their associations with C-peptide were evaluated for those participants who visited the hospital at least twice.

11.1% of the participants had previous type 2 diabetes. In the participants without previous type 2 diabetes, the relationships between fasting C-peptide and hs-CRP and hs-cTnT were negative if the value of fasting C-peptide was < 1.4 ng/mL and positive if the value was ≥ 1.4 ng/mL. The study observed that the association between C-peptide and cardiovascular risk looked like the shape of a tick sign or “V” character in the adults without diabetes and those with newly diagnosed type 2 diabetes.

The researchers opined that the effect of C-peptide on cardiovascular risk may be bidirectional, negative under a lower level of C-peptide and positive under a higher level, in adults without diabetes and patients with early diagnosed T2DM.

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