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5. Is diabetes remission possible with achievable weight loss?

      With the ever-changing lifestyle modifications, we invite many lifestyle diseases as guests to be beside us or with us. Diabetes is one of those invitees that burdened the life of millions of people among us. The seriousness of the disease lies in the fact that if left uncared it will lead to many complications such as the increased risk of heart disease, stroke, blindness, and even amputations. However, the positive element in the management and care of diabetes is that it can be managed through amalgamating positive lifestyle changes and medication. Diabetes researches had shown that it is even possible for the high blood glucose levels that define diabetes to return to normal through significant calorie restriction and weight loss.

      In a recent study from Cambridge on this perspective named the ADDITION-Cambridge trial, found that an intensive low-calorie diet involving a total daily intake of 700 calories for a period of 8 weeks aids in the remission of diabetes in people who are recently diagnosed with diabetes and in people with longstanding disease. It was a prospective cohort study in 867 people with newly diagnosed diabetes aged 40–69 years. The study subjects had gone through an assessment of weight change and physical activity using EPAQ2 questionnaire, for diet, plasma vitamin C and self-report and a self report of alcohol consumption at baseline and 1 year after diagnosis. Remission was examined at 5 years after diabetes diagnosis through the HbA1c level. The results from the study revealed that during a period of five year follow up about 30% of the study population were found in the remission and a two-fold increase in the percentage of subjects who attained a 10% weight loss or more within the first five years after diagnosis to be more likely to be in a state of remission compared to those with same weight.

      The study suggests the possibility of biochemical remission of type 2 diabetes without the intervention of pharmacology and intensive calorie interventions and weight loss. ADDITION-Cambridge trial concludes that by paying considerable attention to achieve weight loss following a diagnosis of Type 2 diabetes, avoiding the risk of type 2 diabetes or even a stage of remission is not beyond the reach for people with diabetes.

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