Diabetes researches report that a high sensitivity C-reactive
protein is associated with the prevalence of diabetic nephropathy (DN) but its association
with the incidence of DN is not yet explored. On this aspect, a recent study was conducted
in African Americans termed as the Jackson Heart Study.
The study was conducted as a longitudinal analysis of data with 4,043 eligible Jackson
Heart Study (JHS) participants. Incident DN was defined as urinary albumin-to-cretinine
ratio (ACR) >30 mg/g or self-reported dialysis/transplantation and type 2 diabetes mellitus
(DM) or HbA1c >6.5%. Kaplan-Meier curves were used to examine DN event-free survival
probability by hs-CRP. With Cox proportional hazards regression estimated hazard ratios
(HRs) and 95% CI for DN by hs-CRP tertiles, adjusting for demographics and clinical and
During 7.8 years of median follow-up time, participants who developed DN had significantly
higher baseline hs-CRP, age, fasting glucose, triglycerides, ACR, systolic blood pressure,
waist circumference, and duration of DM (P < 0.05). The overall incident rate of DN was
7.9%. The mean time to incident DN was shorter for participants with hs-CRP in the high tertile (
>4.24 mg/L) than in the low tertile (<1.46 mg/L).Participants with high hs-CRP were found to had
higher incidence of DN (HR 2.34, 95% CI 1.04–5.24) compared to the reference group. Inflammation,
as measured by hs-CRP levels, may be associated with incident DN in AA.
From the results of the study, it can be stated that hs-CRP is associated not only with the
prevalence of DN but also with the incidence of DN.