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Welcome to the September Issue of GEMS!
Celebrating Onam with Wisdom, Wellness, and Smarter Diabetes Management
As the vibrant festival of Onam fills our homes with color, tradition, and celebration, it also reminds us of the delicate balance between indulgence and health—especially for individuals living with diabetes.
This month’s issue brings fresh perspectives from global diabetes research, focusing on lesser-known but critical aspects of metabolic health. We begin with a fascinating study on Metformin’s hidden impact on essential metals like copper, iron, and zinc. Beyond blood glucose control, this common medication might be fine-tuning metabolic pathways in ways that explain its broader protective effects, from cardiovascular disease to cancer risk reduction.
Also in this issue, we uncover a hidden but critical threat: smoking’s direct role in triggering all four subtypes of type 2 diabetes.
We also explore the real impact of protein choices on cancer risk in our Research Brief. Surprisingly, moderate consumption of lean animal protein was linked to lower cancer mortality, challenging old myths and supporting a balanced dietary approach for people with diabetes.
In a breakthrough that could redefine type 1 diabetes care, a first-in-human trial shows that CRISPR-edited islet cells can now evade immune rejection and restore insulin secretion—without immunosuppression. It’s a bold leap toward curative therapies, blending precision medicine with regenerative hope.
From a public health standpoint, we feature a compelling study on Relative Fat Mass (RFM)—a simple, tape-measure–based metric that outperforms BMI in predicting diabetes risk, especially in younger adults and women. As diabetes prevention strategies evolve, tools like RFM may lead the way in proactive, personalized screening.
We continue our nutrition theme with a comprehensive piece on plant-based diets, showing how even a partial shift toward plant-rich eating can protect against multiple chronic diseases. With festive meals on the horizon, this gentle dietary nudge is both timely and actionable.
To bring this science to your plate, our GEMS Recipe of the Month features a Spiced Tofu Veggie Scramble—a protein-packed, flavorful dish. Perfect for breakfast or brunch during the Onam holidays, it’s a festival-friendly, diabetes-conscious choice.
In this month’s Drug Update, we feature Enlicitide, a novel oral PCSK9 inhibitor that offers powerful LDL-C lowering without injections. As a once-daily pill, it brings convenience and accessibility to advanced cholesterol management, especially for those who struggle with injectable therapies.
This month, GEMS features an important device update on Tandem’s newly FDA-cleared 7-day Steady Set infusion system. Designed for improved comfort and ease of use, this innovative set offers a 35° angled cannula, kink-resistant design, and a simplified push and twist tubing connection set to launch in 2026.
Don’t miss this issue’s Picture of the Month, where we spotlight Inclisiran—another PCSK9-targeting breakthrough, but with just two injections per year. It’s redefining lipid-lowering therapy with simplicity, strength, and science.
Finally, our Video of the Month by Dr. Jothydev Kesavadev addresses a pressing concern: why seemingly healthy young adults are collapsing during exercise. His eye-opening insights explore the hidden cardiac risks of unprepared workouts, making this video essential viewing before your next gym session or post-Onam fitness resolution.
As we celebrate Onam’s message of abundance and renewal, GEMS invites you to embrace a similar approach to diabetes care—abundant in knowledge, and renewed in commitment. May this festive season inspire not only cultural joy but also health-conscious choices that last long after the celebrations end.
Wishing you a happy, healthy, and empowered Onam!
To visit our previous issues, click here
Thanking you once again for the comments and suggestions. If in case you are not interested in receiving this free monthly scientific newsletter, kindly reply with "delete gems" in the subject line to info@jothydev.net
Regards
JDC Diabetes Gems Team
Jothydev's Diabetes and Research Centres
Trivandrum, Attingal and Kochi, Kerala, INDIA
+91 9846040055, +91 9562040055
, +91 9746366655
http://www.jothydev.net
Welcome to the September Issue of GEMS!
Celebrating Onam with Wisdom, Wellness, and Smarter Diabetes Management
As the vibrant festival of Onam fills our homes with color, tradition, and celebration, it also reminds us of the delicate balance between...indulgence and health—especially for individuals living with diabetes.
This month’s issue brings fresh perspectives from global diabetes research, focusing on lesser-known but critical aspects
of metabolic health. We begin with a fascinating study on Metformin’s hidden impact on essential metals like copper,
iron, and zinc. Beyond blood glucose control, this common medication might be fine-tuning metabolic pathways in ways that
explain its broader protective effects, from cardiovascular disease to cancer risk reduction.
Also in this issue, we uncover a hidden but critical threat: smoking’s direct role in triggering all four subtypes of type 2 diabetes.
We also explore the real impact of protein choices on cancer risk in our Research Brief. Surprisingly, moderate consumption of
lean animal protein was linked to lower cancer mortality, challenging old myths and supporting a balanced dietary approach for
people with diabetes.
In a breakthrough that could redefine type 1 diabetes care, a first-in-human trial shows that CRISPR-edited islet cells can
now evade immune rejection and restore insulin secretion—without immunosuppression. It’s a bold leap toward curative therapies,
blending precision medicine with regenerative hope.
From a public health standpoint, we feature a compelling study on Relative Fat Mass (RFM)—a simple, tape-measure–based metric that
outperforms BMI in predicting diabetes risk, especially in younger adults and women. As diabetes prevention strategies evolve, tools
like RFM may lead the way in proactive, personalized screening.
We continue our nutrition theme with a comprehensive piece on plant-based diets, showing how even a partial shift
toward plant-rich eating can protect against multiple chronic diseases. With festive meals on the horizon, this gentle
dietary nudge is both timely and actionable.
To bring this science to your plate, our GEMS Recipe of the Month features a Spiced Tofu Veggie Scramble—a protein-packed,
flavorful dish. Perfect for breakfast or brunch during the Onam holidays, it’s a festival-friendly, diabetes-conscious choice.
In this month’s Drug Update, we feature Enlicitide, a novel oral PCSK9 inhibitor that offers powerful LDL-C lowering without
injections. As a once-daily pill, it brings convenience and accessibility to advanced cholesterol management, especially for
those who struggle with injectable therapies.
This month, GEMS features an important device update on Tandem’s newly FDA-cleared 7-day Steady Set infusion system.
Designed for improved comfort and ease of use, this innovative set offers a 35° angled cannula, kink-resistant design,
and a simplified push and twist tubing connection set to launch in 2026.
Don’t miss this issue’s Picture of the Month, where we spotlight Inclisiran—another PCSK9-targeting breakthrough,
but with just two injections per year. It’s redefining lipid-lowering therapy with simplicity, strength, and science.
Finally, our Video of the Month by Dr. Jothydev Kesavadev addresses a pressing concern: why seemingly healthy young adults
are collapsing during exercise. His eye-opening insights explore the hidden cardiac risks of unprepared workouts, making this
video essential viewing before your next gym session or post-Onam fitness resolution.
As we celebrate Onam’s message of abundance and renewal, GEMS invites you to embrace a similar approach to diabetes
care—abundant in knowledge, and renewed in commitment. May this festive season inspire not only cultural joy but also
health-conscious choices that last long after the celebrations end.
Wishing you a happy, healthy, and empowered Onam!
To visit our previous issues,
click here
Thanking you once again for the comments and suggestions. If in case you are not interested in receiving this free monthly scientific newsletter, kindly reply with "delete gems" in the subject line to info@jothydev.net
Regards
JDC Diabetes Gems Team
Jothydev's Diabetes and Research Centres
Trivandrum, Attingal and Kochi, Kerala, INDIA
+91 9846040055, +91 9562040055
,+91 9746366655
http://www.jothydev.net
Gems picture of the month
Inclisiran is a cutting-edge siRNA-based therapy that silences the PCSK9 gene in the liver, leading to dramatic and sustained reductions..........
Gems picture of the month
Inclisiran is a cutting-edge siRNA-based therapy that silences the PCSK9 gene in the liver, leading to dramatic and sustained reductions...........
GEMS Research Spotlight: How Metformin Alters Metal Levels in the Body — And Why It Matters
Metformin has long been the go-to drug for treating type 2 diabetes. It helps lower blood glucose, improve insulin sensitivity, and......... READ MORE
Smoking: A Hidden Driver of All Subtypes of Type 2 Diabetes
We’ve long known that smoking raises the risk of heart disease and cancer, but did you know it can also directly contribute to every........ READ MORE
GEMS Research Brief: Can Eating More Animal Protein Reduce Cancer Deaths?
Protein is essential, but what kind matters too. Many people assume that plant protein is healthier than animal sources, especially........ READ MORE
CRISPR-Engineered Islet Cells Evade Immune Rejection and Restore Insulin Secretion in First-in-Human Study
Islet transplantation has long been recognized as a promising therapy for Type 1 Diabetes Mellitus (T1DM). However, the......... READ MORE
Relative Fat Mass (RFM): A Better Predictor of Diabetes Than BMI?
Traditional tools like Body Mass Index (BMI) have long been used to assess obesity-related health risks, including type 2......... READ MORE
Plant-Based Diets: A Natural Shield Against Multiple Chronic Diseases
Can what’s on your plate today protect you from multiple diseases tomorrow? A growing body of research says yes,......... READ MORE
Device and Drug Updates
This month, GEMS features an important device update on Tandem’s newly FDA-cleared 7-day Steady Set infusion.......... READ MORE
Recipe of the Month
Spiced Tofu Veggie Scramble
Looking for a vibrant, protein-rich alternative to your usual meal? This colourful tofu scramble brings together..........
READ MORE
JDC Updates
In response to the alarming rise in sudden cardiac events among young adults in Kerala, especially during or immediately after........ READ MORE
The Newsletter team:
Chief Editor : Dr.Jothydev KesavadevManaging Editor : Sunitha Jothydev
Editor : Dr.Arun Shankar
Scientific Editor : Gopika Krishnan (Research Head, JDC Centres)
Sub Editors : Sree Lekshmi R, Anjana Basanth, Geethu Sanal
Webpage Editor : Deepu J S
Founder Editor : Neethu Annie Ajai
For enquiries info@jothydev.net.
Please visit: jothydev.net | research.jothydev.com | diabscreenkerala.net | jothydev.com/newsletter